Shape Ultrasound with Dynamic Microfluidic Lenses

Abstract

Dynamic shaping of ultrasound into prescribed spatial patterns underlies a broad range of biomedical and engineering applications. However, existing modulation strategies face fundamental limitations: single element transducers paired with acoustic lenses lack reconfigurability, whereas phased arrays require large numbers of independently driven elements, leading to substantial hardware complexity, cost, and rigidity. Here we introduce a microfluidic ultrasound lens system that enables reconfigurable spatial modulation of ultrasonic fields using two orthogonal layers of soft microfluidic channels. Each channel is selectively filled with one of two liquids with distinct sound speeds via an FPGA controlled array of micropumps, generating programmable binary phase patterns. Integrating a 20-row-by-20-column microfluidic lens with a single element transducer, we demonstrate three-dimensional ultrasound focusing with approximately one second reconfiguration time and spatial resolution comparable to that of a 400-element transducer array. The system provides 400 addressable pixels through parallel control of 80 pumps, allowing hardware complexity to scale with the square root of the pixel count. Building on this platform, we demonstrate dynamic ultrasound heating, as well as remote particle manipulation. Furthermore, we demonstrate a cylindrical lens that manipulates ultrasound propagation in the azimuthal direction. Owing to its liquid based, soft architecture, the microfluidic lens offers design flexibility, scalable operation across ultrasound frequencies, low acoustic transmission loss, and stable performance under high acoustic power. Together, these results establish microfluidic phase modulation as a compact, scalable, and flexible approach for dynamic ultrasound field control.