Clinically-aligned ischemic stroke segmentation and ASPECTS scoring on NCCT imaging using a slice-gated loss on foundation representations

Abstract

Rapid infarct assessment on non-contrast CT (NCCT) is essential for acute ischemic stroke management. Most deep learning methods perform pixel-wise segmentation without modeling the structured anatomical reasoning underlying ASPECTS scoring, where basal ganglia (BG) and supraganglionic (SG) levels are clinically interpreted in a coupled manner. We propose a clinically aligned framework that combines a frozen DINOv3 backbone with a lightweight decoder and introduce a Territory-Aware Gated Loss (TAGL) to enforce BG-SG consistency during training. This anatomically informed supervision adds no inference-time complexity. Our method achieves a Dice score of 0.6385 on AISD, outperforming prior CNN and foundation-model baselines. On a proprietary ASPECTS dataset, TAGL improves mean Dice from 0.698 to 0.767. These results demonstrate that integrating foundation representations with structured clinical priors improves NCCT stroke segmentation and ASPECTS delineation.